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Zinc‐Promoted Hydrohydrazination of Terminal Alkynes: An Efficient Domino Synthesis of Indoles
Author(s) -
Alex Karolin,
Tillack Annegret,
Schwarz Nicolle,
Beller Matthias
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703823
Subject(s) - domino , zinc , indole test , trifluoromethanesulfonate , chemistry , catalysis , combinatorial chemistry , intermolecular force , organic chemistry , molecule
Indole click chemistry : The quest for better catalysts for the intermolecular hydrohydrazination to indoles leads to zinc salts. A simple one‐pot synthesis forms indoles from arylhydrazines and terminal alkynes. The pharmacologically relevant indole building blocks are selectively formed in the presence of zinc triflate (Zn(OTf) 2 ) or ZnCl 2 (see scheme).
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