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Total Synthesis of Azadirachtin—Finally Completed After 22 Years
Author(s) -
Jauch Johann
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703814
Subject(s) - azadirachtin , total synthesis , patience , natural product , milestone , product (mathematics) , natural (archaeology) , chemistry , geography , mathematics , philosophy , stereochemistry , biology , ecology , archaeology , theology , pesticide , geometry
Patience pays off : 22 years ago Ley and co‐workers started their project on the synthesis of azadirachtin ( 1 )—a project which they recently completed successfully with the first total synthesis of this complex natural product. This milestone of natural product synthesis is acknowledged in this Highlight. Tig=tigloyl=( E )‐2‐methyl‐2‐butenoyl