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Reassignment of the Structure of the Antibiotic A53868 Reveals an Unusual Amino Dehydrophosphonic Acid
Author(s) -
Whitteck John T.,
Ni Weijuan,
Griffin Benjamin M.,
Eliot Andrew C.,
Thomas Paul M.,
Kelleher Neil L.,
Metcalf William W.,
van der Donk Wilfred A.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703810
Subject(s) - phosphonate , antibiotics , chemistry , charm (quantum number) , content (measure theory) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , physics , mathematics , mathematical analysis , quantum mechanics
Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus , has proven quite elusive. Originally reported as 1 and later revised to 2 , the actual structure of the compound is the unusual dehydro aminophosphonic acid 3 .