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Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin
Author(s) -
Nicolaou K. C.,
Cole Kevin P.,
Frederick Michael O.,
Aversa Robert J.,
Denton Ross M.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703742
Subject(s) - ring (chemistry) , chemistry , stereochemistry , marine toxin , molecule , computational chemistry , organic chemistry , biochemistry , toxin
Accepting the proposal : The originally proposed structure of maitotoxin has recently come under scrutiny based on biosynthetic and computational considerations. A newly synthesized ring framework corresponding to the GHIJK ring domain (see structure) of the molecule provided, through 13 C NMR spectroscopic comparisons, strong experimental support for the originally proposed structure.