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Catalytic Enantioselective 1,6‐Conjugate Addition of Grignard Reagents to Linear Dienoates
Author(s) -
den Hartog Tim,
Harutyunyan Syuzanna R.,
Font Daniel,
Minnaard Adriaan J.,
Feringa Ben L.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703702
Subject(s) - enantioselective synthesis , reagent , catalysis , conjugate , ligand (biochemistry) , chemistry , combinatorial chemistry , organic chemistry , mathematics , mathematical analysis , biochemistry , receptor
Dual function of catalyst: Both regio‐ and enantioselectivity are dictated by Cu catalysis using the reversed josiphos ligand. This allows enantioselective 1,6‐addition of Grignard reagents to acyclic α,β,γ,δ‐unsaturated esters monosubstituted at the β and δ positions (see scheme).
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