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DNA‐Catalyzed Formation of Nucleopeptide Linkages
Author(s) -
Pradeepkumar P. I.,
Höbartner Claudia,
Baum Dana A.,
Silverman Scott K.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703676
Subject(s) - oligonucleotide , nucleotide , rna , deoxyribozyme , dna , chemistry , ribozyme , scope (computer science) , biochemistry , nucleophile , catalysis , computational biology , stereochemistry , combinatorial chemistry , biology , gene , computer science , programming language
Joining amino acids and nucleotides : A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′‐triphosphate RNA, efficiently forming a Tyr–RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups.
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