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Chiral Olefins as Steering Ligands in Asymmetric Catalysis
Author(s) -
Defieber Christian,
Grützmacher Hansjörg,
Carreira Erick M.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703612
Subject(s) - stereocenter , heteroatom , enantioselective synthesis , olefin fiber , chelation , catalysis , metal , combinatorial chemistry , chemistry , asymmetric carbon , chirality (physics) , stereochemistry , organic chemistry , optically active , ring (chemistry) , chiral anomaly , physics , fermion , quantum mechanics , nambu–jona lasinio model
Metal‐catalyzed asymmetric processes offer one of the most straightforward ways to introduce stereogenic centers. Hence, the development of novel chiral ligands that can effectively induce asymmetry in reactions is crucial in modern organic synthesis. While many established chiral ligands bind to a metal through heteroatoms, structures that coordinate to metals through carbon atoms have received little attention so far. Here, we highlight the increasing number of such chiral chelating olefin ligands as well as their application in a variety of metal‐catalyzed transformations.