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Multifunctional Magneto‐Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer
Author(s) -
Yang Jaemoon,
Lee ChoongHwan,
Ko HyunJu,
Suh JinSuck,
Yoon HoGeun,
Lee Kwangyeol,
Huh YongMin,
Haam Seungjoo
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703554
Subject(s) - amphiphile , copolymer , breast cancer , materials science , cancer , nanotechnology , magneto , cancer research , biomedical engineering , medicine , chemistry , polymer , organic chemistry , composite material , combustion
Diagnosis and treatment all in one : Multifunctional magneto‐polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe 2 O 4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2 ‐weighted MR images (top row) and color map (bottom row) of the relaxivity R 2 for NIH3T6.7 and MDA‐MB‐231 cells.