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Comparative Properties of Insulin‐like Growth Factor 1 (IGF‐1) and [Gly7D‐Ala]IGF‐1 Prepared by Total Chemical Synthesis
Author(s) -
Sohma Youhei,
Pentelute Brad L.,
Whittaker Jonathan,
Hua Qinxin,
Whittaker Linda J.,
Weiss Michael A.,
Kent Stephen B. H.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703521
Subject(s) - insulin like growth factor , folding (dsp implementation) , scheme (mathematics) , chemistry , computational biology , growth factor , computer science , biochemistry , combinatorial chemistry , receptor , mathematics , biology , engineering , mathematical analysis , electrical engineering
Chemistry for biology : IGF‐1 and [Gly7D‐Ala]IGF‐1 have been prepared by a total chemical synthesis and their folding and receptor‐binding properties compared (see scheme). This approach facilitates the introduction of nonstandard amino acids whose biosynthetic incorporation is difficult or not feasible and thus promises to lead to a new generation of structure–activity studies of potential interest in the treatment of cancer and diabetes mellitus.