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Total Synthesis and Configurational Assignment of Pasteurestin A and B
Author(s) -
Kögl Marion,
Brecker Lothar,
Warrass Ralf,
Mulzer Johann
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703457
Subject(s) - cycloaddition , computer science , stereochemistry , chemistry , content (measure theory) , combinatorics , combinatorial chemistry , mathematics , organic chemistry , catalysis , mathematical analysis
Fresh pasture for the [2+2+2] cycloaddition : The two sesquiterpenoids pasteurestin A and B, which exhibit strong and selective antibacterial activity against Pasteurella haemolytica , have been prepared in a synthesis relying on a [2+2+2] Vollhardt enediyne cycloaddition. The previously unknown absolute and relative configurations were established, and the biological profile was specified more precisely.