Bulky Chiral Carbene Ligands and Their Application in the Palladium‐Catalyzed Asymmetric Intramolecular α‐Arylation of Amides | Zendy

Kündig E. Peter | Zendy; Seidel Thomas M. | Zendy; Jia Yixia | Zendy; Bernardinelli Gérald | Zendy

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Bulky Chiral Carbene Ligands and Their Application in the Palladium‐Catalyzed Asymmetric Intramolecular α‐Arylation of Amides

Author(s) -

Kündig E. Peter,

Seidel Thomas M.,

Jia Yixia,

Bernardinelli Gérald

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703408

Subject(s) - carbene , intramolecular force , palladium , chemistry , yield (engineering) , enantiomer , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , materials science , metallurgy

Bring on the big cats : New, C 2 ‐symmetric bulky N‐heterocyclic carbene ligands bring major improvements in the palladium‐catalyzed asymmetric intramolecular α‐arylation of amides to give oxindoles (see picture, dba= trans , trans ‐dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.

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