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Bulky Chiral Carbene Ligands and Their Application in the Palladium‐Catalyzed Asymmetric Intramolecular α‐Arylation of Amides
Author(s) -
Kündig E. Peter,
Seidel Thomas M.,
Jia Yixia,
Bernardinelli Gérald
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703408
Subject(s) - carbene , intramolecular force , palladium , chemistry , yield (engineering) , enantiomer , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , materials science , metallurgy
Bring on the big cats : New, C 2 ‐symmetric bulky N‐heterocyclic carbene ligands bring major improvements in the palladium‐catalyzed asymmetric intramolecular α‐arylation of amides to give oxindoles (see picture, dba= trans , trans ‐dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.