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Catalytic Deprotection of Acetals in Basic Solution with a Self‐Assembled Supramolecular “Nanozyme”
Author(s) -
Pluth Michael D.,
Bergman Robert G.,
Raymond Kenneth N.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703371
Subject(s) - supramolecular chemistry , hydrolysis , cleavage (geology) , chemistry , catalysis , combinatorial chemistry , supramolecular catalysis , acetal , organic chemistry , molecule , materials science , fracture (geology) , composite material
Changing on the inside : Acetals are a commonly used protecting groups for aldehydes and ketones in organic synthesis because of their ease of installation and resistance to cleavage in neutral or basic solution. A self‐assembled supramolecular assembly has been shown to catalyze the hydrolysis of acetals and ketals in basic solution (see scheme).