Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction | Zendy

Voss Constance V. | Zendy; Gruber Christian C. | Zendy; Kroutil Wolfgang | Zendy

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Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction

Author(s) -

Voss Constance V.,

Gruber Christian C.,

Kroutil Wolfgang

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703296

Subject(s) - enantioselective synthesis , alcohol dehydrogenase , chemistry , alcohol , enantiomer , stereoselectivity , enantiomeric excess , alcohol oxidation , alkyl , biocatalysis , kinetic resolution , yield (engineering) , biotransformation , combinatorial chemistry , organic chemistry , enzyme , stereochemistry , catalysis , reaction mechanism , materials science , metallurgy

Breaking the mirror : A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in >99 % yield (see scheme). R,R′=alkyl.

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