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Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction
Author(s) -
Voss Constance V.,
Gruber Christian C.,
Kroutil Wolfgang
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703296
Subject(s) - enantioselective synthesis , alcohol dehydrogenase , chemistry , alcohol , enantiomer , stereoselectivity , enantiomeric excess , alcohol oxidation , alkyl , biocatalysis , kinetic resolution , yield (engineering) , biotransformation , combinatorial chemistry , organic chemistry , enzyme , stereochemistry , catalysis , reaction mechanism , materials science , metallurgy
Breaking the mirror : A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in >99 % yield (see scheme). R,R′=alkyl.