Water‐Compatible Iminium Activation: Organocatalytic Michael Reactions of Carbon‐Centered Nucleophiles with Enals | Zendy

Palomo Claudio | Zendy; Landa Aitor | Zendy; Mielgo Antonia | Zendy; Oiarbide Mikel | Zendy; Puente Ángel | Zendy; Vera Silvia | Zendy

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Water‐Compatible Iminium Activation: Organocatalytic Michael Reactions of Carbon‐Centered Nucleophiles with Enals

Author(s) -

Palomo Claudio,

Landa Aitor,

Mielgo Antonia,

Oiarbide Mikel,

Puente Ángel,

Vera Silvia

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703261

Subject(s) - enantioselective synthesis , nucleophile , rolipram , catalysis , iminium , chemistry , michael reaction , organocatalysis , carbon fibers , organic chemistry , combinatorial chemistry , phosphodiesterase , computer science , algorithm , enzyme , composite number

A pool of water ‐compatible catalysts, namely the chiral prolinol‐based catalysts 1 , has been developed for highly enantioselective CC bond‐forming Michael reactions in water (see scheme). The synthesis of ( S )‐Rolipram, a type IV phosphodiesterase inhibitor, was also demonstrated.

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