Premium
Oligopyrrole Synthesis by 1,3‐Dipolar Cycloaddition of Azomethine Ylides with Bissulfonyl Ethylenes
Author(s) -
LópezPérez Ana,
RoblesMachín Rocío,
Adrio Javier,
Carretero Juan Carlos
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703258
Subject(s) - cycloaddition , pyrrole , sulfonyl , chemistry , ethylene , combinatorial chemistry , computer science , iterative method , 1,3 dipolar cycloaddition , medicinal chemistry , organic chemistry , algorithm , catalysis , alkyl
One by one or two by two : In a general approach to the iterative construction of oligopyrroles, the cycloaddition of azomethine ylides derived from pyrrolyl α‐iminoesters with 1,2‐bis(phenylsulfonyl)ethylene is followed by the elimination of the sulfonyl groups in situ under basic conditions. This strategy is amenable to the introduction of one or two pyrrole units in each iterative cycle.