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Efficient Synthesis of Nucleoside Diphosphate Glycopyranoses
Author(s) -
Wendicke Silke,
Warnecke Svenja,
Meier Chris
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703237
Subject(s) - nucleoside , thymine , chemistry , pyranose , stereochemistry , phosphate , biochemistry , dna
Short and sweet : A new, short synthetic pathway for the synthesis of the enormously important class of nucleoside diphosphate sugars (NDP sugars) was developed using cyclo ‐saligenyl (cyclo Sal) nucleosyl phosphate triesters as active ester equivalents that form the target compounds in the presence of anomerically pure pyranose 1‐phosphates in high yields (see scheme; T= thymine; X=OAc, H; Y=OH, H).