Rapid Detection of  S ‐Adenosyl Homocysteine Using Self‐Assembled Optical Diffraction Gratings | Zendy

Acharya Ghanashyam | Zendy; Chang ChunLi | Zendy; Holland David P. | Zendy; Thompson David H. | Zendy; Savran Cagri A. | Zendy

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Rapid Detection of S ‐Adenosyl Homocysteine Using Self‐Assembled Optical Diffraction Gratings

Author(s) -

Acharya Ghanashyam,

Chang ChunLi,

Holland David P.,

Thompson David H.,

Savran Cagri A.

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703222

Subject(s) - diffraction , conjugated system , detection limit , materials science , optics , nanotechnology , chemistry , optoelectronics , physics , chromatography , polymer , organic chemistry

I saw the SAH : Clinically relevant concentrations of S ‐adenosyl homocysteine (SAH) can be rapidly detected using self‐assembled diffraction gratings. SAH bound to antibody‐conjugated (Ab) microbeads (see picture) and then incubated with a gold chip functionalized with SAH‐specific aptamer in alternating line patterns produces gratings that are detected by optical diffraction intensity measurements (detection limit: 64 pmol L −1 ).

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