Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C | Zendy

Bonazzi Simone | Zendy; Güttinger Stephan | Zendy; Zemp Ivo | Zendy; Kutay Ulrike | Zendy; Gademann Karl | Zendy

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Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Author(s) -

Bonazzi Simone,

Güttinger Stephan,

Zemp Ivo,

Kutay Ulrike,

Gademann Karl

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703134

Subject(s) - enantioselective synthesis , total synthesis , negishi coupling , chemistry , stereochemistry , nucleus , natural product , combinatorial chemistry , catalysis , biochemistry , biology , microbiology and biotechnology

Against nuclear export! Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr‐catalyzed enantioselective hetero‐Diels–Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.

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