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Alkene‐Directed Regioselective Nickel‐Catalyzed Cross‐Coupling of Cyclic Anhydrides with Diorganozinc Reagents
Author(s) -
Rogers Rebecca L.,
Moore Jennifer L.,
Rovis Tomislav
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703124
Subject(s) - alkene , reagent , nickel , regioselectivity , catalysis , chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , stereochemistry , materials science , metallurgy
The ‐enes have it! A resident alkene directs a nickel‐catalyzed cross‐coupling of cyclic anhydrides with diorganozinc reagents. Relative directing effects parallel the stability of nickel–alkene complexes, with less‐hindered terminal olefins dominating over internal olefins.