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A Binuclear Manganese Cluster That Catalyzes Radical‐Mediated N‐Oxygenation
Author(s) -
Winkler Robert,
Zocher Georg,
Richter Ingrid,
Friedrich Thorsten,
Schulz Georg E.,
Hertweck Christian
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703089
Subject(s) - manganese , chemistry , catalysis , biocatalysis , ligand (biochemistry) , mutagenesis , nitro , cluster (spacecraft) , stereochemistry , photochemistry , biochemistry , organic chemistry , reaction mechanism , mutation , alkyl , receptor , computer science , gene , programming language
Site‐directed mutagenesis was used to explore the ligand sphere and geometry of a novel binuclear manganese biocatalyst (see picture; Mn green, C gray, O red, N blue) that oxidizes amino to nitro groups with high specificity. The involvement of Mn in catalysis and radical formation was unequivocally proven by ESR spectroscopy.