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Teaching Bacteria New Tricks—With RNA Switches
Author(s) -
Hartig Jörg S.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703088
Subject(s) - bacteria , rna , computational biology , biology , motility , nanotechnology , chemistry , microbiology and biotechnology , genetics , gene , materials science
A demanding challenge for the genetic modification of organisms that could target pollutants or diseases in future applications will be the recruitment of such entities to the respective sites of action. Topp and Gallivan have used RNA switches to guide bacteria along paths of specific compounds by rewiring their chemosensory system (see picture; the CheZ protein controls the motility).