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Structural “Snapshots” along Reaction Pathways of Non‐Heme Iron Enzymes
Author(s) -
Emerson Joseph P.,
Farquhar Erik R.,
Que Lawrence
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703057
Subject(s) - heme , enzyme , chemistry , biochemistry , oxygen , detoxification (alternative medicine) , superoxide , hemeprotein , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
Recent X‐ray crystallography studies on two non‐heme iron enzymes (see picture, orange Fe, red O, blue N) involved in oxygen activation and superoxide detoxification have provided unique structural insights into intermediates in their individual reaction pathways. The results of these studies and their mechanistic significance are discussed.