Organocuprate Cross‐Coupling: The Central Role of the Copper(III) Intermediate and the Importance of the Copper(I) Precursor | Zendy

Bertz Steven H. | Zendy; Cope Stephen | Zendy; Dorton Donna | Zendy; Murphy Michael | Zendy; Ogle Craig A. | Zendy

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Organocuprate Cross‐Coupling: The Central Role of the Copper(III) Intermediate and the Importance of the Copper(I) Precursor

Author(s) -

Bertz Steven H.,

Cope Stephen,

Dorton Donna,

Murphy Michael,

Ogle Craig A.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200703035

Subject(s) - tetracoordinate , copper , reagent , chemistry , coupling (piping) , range (aeronautics) , planar , organic chemistry , computer science , materials science , metallurgy , composite material , computer graphics (images)

Cu III in focus : The key intermediate in copper‐mediated cross‐coupling reactions has long been believed to be a “copper(III) intermediate”. Investigation of reactions of a variety of methyl Gilman reagents Me 2 CuLi⋅LiX with EtI using rapid‐injection NMR spectroscopy conditions reveals a number of formally Cu III tetracoordinate square‐planar intermediates (see scheme) with a surprising range of stabilities.

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