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A General Method for the Direct α‐Arylation of Aldehydes with Aryl Bromides and Chlorides
Author(s) -
Martín Rubén,
Buchwald Stephen L.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703009
Subject(s) - scope (computer science) , aryl , variety (cybernetics) , substitution (logic) , scheme (mathematics) , combinatorial chemistry , computer science , catalysis , chemistry , content (measure theory) , organic chemistry , mathematics , programming language , artificial intelligence , mathematical analysis , alkyl
Wide scope : A catalyst system able to efficiently perform the title reaction is described (see scheme). The high level of activity achieved allows for the synthesis of highly functionalized compounds with a wide variety of substitution patterns under very mild conditions.