Premium
Recognition of “Mirror‐Image” DNA by Small Molecules
Author(s) -
Dose Christian,
Ho Dominik,
Gaub Hermann E.,
Dervan Peter B.,
Albrecht Christian H.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703007
Subject(s) - dna , diastereomer , molecule , enantiomer , chemistry , stereochemistry , crystallography , biochemistry , organic chemistry
May the force be with you : “Mirror‐image” hairpin polyamides distinguish the L enantiomer of DNA ( L ‐DNA) in the presence of natural DNA ( D ‐DNA). This specificity is investigated by a molecular force balance at a single‐molecule level. The “DNA balance” allows the measurement of rupture forces of match/mismatch diastereomeric complexes in a single experiment.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom