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Regio‐ and Enantioselective Direct Oxyamination Reaction of Aldehydes Catalyzed by α,α‐Diphenylprolinol Trimethylsilyl Ether
Author(s) -
Palomo Claudio,
Vera Silvia,
Velilla Irene,
Mielgo Antonia,
GómezBengoa Enrique
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200703001
Subject(s) - enantioselective synthesis , chemistry , nitrosobenzene , catalysis , trimethylsilyl , ether , organic chemistry
Donors not required : External hydrogen‐bond donors are not required for a highly regio‐ and enantioselective oxyamination reaction of aldehydes with nitrosobenzene (see scheme). The reaction proceeds in the presence of the structurally simple organocatalyst (−)‐( S )‐α,α‐diphenylprolinol trimethylsilyl ether to afford the oxyaminated compounds in good yields.