Palladium‐Catalyzed Aminocarbonylation of Aryl Chlorides at Atmospheric Pressure: The Dual Role of Sodium Phenoxide | Zendy

Martinelli Joseph R. | Zendy; Clark Thomas P. | Zendy; Watson Donald A. | Zendy; Munday Rachel H. | Zendy; Buchwald Stephen L. | Zendy

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Palladium‐Catalyzed Aminocarbonylation of Aryl Chlorides at Atmospheric Pressure: The Dual Role of Sodium Phenoxide

Author(s) -

Martinelli Joseph R.,

Clark Thomas P.,

Watson Donald A.,

Munday Rachel H.,

Buchwald Stephen L.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702943

Subject(s) - catalysis , palladium , aryl , carbonylation , chemistry , atmospheric pressure , sodium , ligand (biochemistry) , functional group , transformation (genetics) , dual (grammatical number) , combinatorial chemistry , organic chemistry , carbon monoxide , receptor , art , biochemistry , alkyl , oceanography , polymer , literature , gene , geology

No pressure, no worries : A general, functional‐group‐tolerant, mild system for the Pd‐catalyzed carbonylation of aryl chlorides to the corresponding amides has been developed. The catalyst operates at 1 atm CO using an inexpensive, air‐stable, and commercially available ligand (see scheme, Cy=cyclohexyl). Sodium phenoxide is a critical additive in this transformation; its role has been studied using in situ IR spectroscopy.

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