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The Fatty Acid Factory of Yeasts
Author(s) -
Kolter Thomas
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702930
Subject(s) - yeast , biochemistry , fatty acid , cytoplasm , enzyme , biology , chemistry
Fatty acids are essential metabolites for nearly all organisms. Yeasts, fungi, and animals synthesize them using fatty acid synthases of type I (FAS I) in the cytoplasm, whereby the FAS I of animals is distinct from that of fungi and yeasts. Recently obtained high‐resolution X‐ray structures of the 2.6‐MDa FAS enzyme from yeast and fungi (see picture) now allow a closer look at the mechanism of this reaction.