Solid‐State Protein‐Structure Determination with Proton‐Detected Triple‐Resonance 3D Magic‐Angle‐Spinning NMR Spectroscopy | Zendy

Zhou Donghua H. | Zendy; Shea John J. | Zendy; Nieuwkoop Andrew J. | Zendy; Franks W. Trent | Zendy; Wylie Benjamin J. | Zendy; Mullen Charles | Zendy; Sandoz Dennis | Zendy; Rienstra Chad M. | Zendy

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Solid‐State Protein‐Structure Determination with Proton‐Detected Triple‐Resonance 3D Magic‐Angle‐Spinning NMR Spectroscopy

Author(s) -

Zhou Donghua H.,

Shea John J.,

Nieuwkoop Andrew J.,

Franks W. Trent,

Wylie Benjamin J.,

Mullen Charles,

Sandoz Dennis,

Rienstra Chad M.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702905

Subject(s) - magic angle spinning , microcrystalline , spinning , nuclear magnetic resonance spectroscopy , solid state nuclear magnetic resonance , spectroscopy , magic (telescope) , magic angle , chemistry , physics , analytical chemistry (journal) , materials science , crystallography , nuclear magnetic resonance , organic chemistry , quantum mechanics , polymer chemistry

Spinning a magical web : The combination of fast magic‐angle spinning, isotopic dilution, and high magnetic field yields particularly well‐resolved solid‐state 1 H NMR spectra, which are efficiently utilized to solve protein structure. New techniques are demonstrated, requiring only three days of data collection, to assign the proton signals and solve a high‐resolution structure of microcrystalline GB1.

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