Polymeric Nanoparticles as Imaging Probes for Protein Kinase Activity in Cells | Zendy

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Polymeric Nanoparticles as Imaging Probes for Protein Kinase Activity in Cells

Author(s) -

Schuster Bernhard

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702853

Subject(s) - nanoparticle , conjugated system , chemistry , biophysics , protein kinase a , peptide , fluorescence , biocompatible material , polymer , kinase , nanotechnology , materials science , biochemistry , biomedical engineering , biology , organic chemistry , medicine , physics , quantum mechanics

Cell‐permeable, biocompatible nanoparticles consisting of a positively charged polymer, which is conjugated to a near‐infrared (NIR) fluorochrome and a protein‐kinase‐specific peptide, and a negatively charged polymer constitute innovative probes for measuring protein kinase activity in living cells. Protein kinase activity selectively induces dissolution of the nanoparticles and is accompanied by a strong NIR fluorescence signal (see scheme).

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