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Synthetic Virus‐Like Particles from Self‐Assembling Coiled‐Coil Lipopeptides and Their Use in Antigen Display to the Immune System
Author(s) -
Boato Francesca,
Thomas Richard M.,
Ghasparian Arin,
FreundRenard Annabelle,
Moehle Kerstin,
Robinson John A.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702805
Subject(s) - antigen , lipopeptide , immune system , virus , coiled coil , nanotechnology , virology , biology , computer science , microbiology and biotechnology , materials science , immunology , bacteria , genetics
Vanquishing viruses : Access to nanoscale particles is provided by synthetic lipopeptide building blocks that self‐assemble into virus‐like particles in aqueous solution, and which can be decorated with synthetic antigens for the purpose of generating humoral antigen‐specific immune responses in vivo.