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Total Syntheses of Lysobactin (Katanosin B)
Author(s) -
Campagne JeanMarc
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702687
Subject(s) - staphylococcus aureus , total synthesis , antibiotics , chemistry , stereochemistry , mode of action , microbiology and biotechnology , vancomycin , biology , bacteria , biochemistry , genetics
Catching up with the bugs : Lysobactin ( 1 ) is a natural cyclodepsipeptide with potent antibiotic activity against vancomycin‐resistant enterococci and methicillin‐resistant Staphylococcus aureus. Two total syntheses of 1 have been published recently which should enable further chemical modifications of the lysobactin structure and a better understanding of its mode of action.