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Distinguishing Anhydrous and Hydrous Forms of an Active Pharmaceutical Ingredient in a Tablet Formulation Using Solid‐State NMR Spectroscopy
Author(s) -
Griffin John M.,
Martin Dave R.,
Brown Steven P.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702582
Subject(s) - active ingredient , anhydrous , ingredient , spectroscopy , nuclear magnetic resonance spectroscopy , solid state , high resolution , chemistry , materials science , organic chemistry , medicine , physics , pharmacology , remote sensing , food science , quantum mechanics , geology
With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high‐resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.

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