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Iridium‐Catalyzed Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Olefins
Author(s) -
Schrems Marcus G.,
Neumann Eva,
Pfaltz Andreas
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702555
Subject(s) - stereocenter , iridium , catalysis , chemistry , boron , trifluoromethyl , asymmetric hydrogenation , organic chemistry , polymer chemistry , enantioselective synthesis , medicinal chemistry , alkyl
Even notoriously unreactive substrates such as tetrasubstituted unfunctionalized olefins can be hydrogenated with high efficiency and excellent enantioselectivity using readily accessible chiral Ir catalysts. In this way, two adjacent stereogenic centers can be introduced in a single step (see scheme for an example; BAr F =tetrakis(3,5‐di(trifluoromethyl)phenyl)borate, o ‐Tol= ortho ‐tolyl).