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Carbohydrate Wheels: Cucurbituril‐Based Carbohydrate Clusters
Author(s) -
Kim Jeeyeon,
Ahn Youngjoo,
Park Kyeng Min,
Kim Youngkook,
Ko Young Ho,
Oh Dong Hyun,
Kim Kimoon
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702540
Subject(s) - cucurbituril , carbohydrate , chemistry , selectivity , scaffold , biophysics , stereochemistry , combinatorial chemistry , supramolecular chemistry , biochemistry , crystallography , crystal structure , computer science , biology , catalysis , database
Steering wheels : Cucurbit[6]uril (CB[6]) can be used as a scaffold to synthesize carbohydrate clusters in which about 11 carbohydrate moieties are attached to the periphery of the rigid macrocycle like a wheel (see picture). The clusters show enhanced selectivity and affinity in binding to specific proteins through multivalent interactions. The CB[6] cavity allows formation of host–guest complexes that can be delivered to specific cells.