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Synthesis and Enantioselectivity of P‐Chiral Phosphine Ligands with Alkynyl Groups
Author(s) -
Imamoto Tsuneo,
Saitoh Youichi,
Koide Aya,
Ogura Tomokazu,
Yoshida Kazuhiro
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702513
Subject(s) - phosphine , borane , chemistry , catalysis , transition metal , asymmetric hydrogenation , nucleophile , combinatorial chemistry , medicinal chemistry , nucleophilic substitution , stereochemistry , enantioselective synthesis , organic chemistry
A range of asymmetric transformations are catalyzed by transition‐metal complexes of the title ligands with excellent enantioselectivities. The ligands, which were applied successively in Rh‐catalyzed hydrogenation and Rh‐ or Pd‐catalyzed CC bond‐forming reactions, were synthesized by nucleophilic substitution of ( R )‐(bromo( tert ‐butyl)methylphosphanyl)borane (see scheme).