Premium
Free Energy Profile of H‐ras Membrane Anchor upon Membrane Insertion
Author(s) -
Gorfe Alemayehu A.,
Babakhani Arneh,
McCammon J. Andrew
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702379
Subject(s) - membrane , bilayer , envelope (radar) , lipid bilayer , chemistry , energy (signal processing) , hydrocarbon , core (optical fiber) , crystallography , stereochemistry , physics , computer science , biochemistry , organic chemistry , optics , telecommunications , radar , quantum mechanics
Pushing the envelope: The calculated free energy profile for the insertion of H‐ras anchor into a dimyristoyl‐ sn ‐glycero‐3‐phosphocholine bilayer shows a steeply downhill profile. The insertion into the hydrocarbon core of the ras lipids and the interfacial localization of the backbone together account for a binding free energy of about −30 kcal mol −1 .