Free Energy Profile of H‐ras Membrane Anchor upon Membrane Insertion | Zendy

Gorfe Alemayehu A. | Zendy; Babakhani Arneh | Zendy; McCammon J. Andrew | Zendy

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Free Energy Profile of H‐ras Membrane Anchor upon Membrane Insertion

Author(s) -

Gorfe Alemayehu A.,

Babakhani Arneh,

McCammon J. Andrew

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702379

Subject(s) - membrane , bilayer , envelope (radar) , lipid bilayer , chemistry , energy (signal processing) , hydrocarbon , core (optical fiber) , crystallography , stereochemistry , physics , computer science , biochemistry , organic chemistry , optics , telecommunications , radar , quantum mechanics

Pushing the envelope: The calculated free energy profile for the insertion of H‐ras anchor into a dimyristoyl‐ sn ‐glycero‐3‐phosphocholine bilayer shows a steeply downhill profile. The insertion into the hydrocarbon core of the ras lipids and the interfacial localization of the backbone together account for a binding free energy of about −30 kcal mol −1 .

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