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Specific DNA Recognition by a Synthetic, Monomeric Cys 2 His 2 Zinc‐Finger Peptide Conjugated to a Minor‐Groove Binder
Author(s) -
Vázquez Olalla,
Vázquez M. Eugenio,
Blanco Juan B.,
Castedo Luis,
Mascareñas José L.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702345
Subject(s) - zinc finger , monomer , dna , conjugated system , minor groove , minor (academic) , peptide , chemistry , zinc , computational biology , groove (engineering) , sequence (biology) , stereochemistry , combinatorial chemistry , computer science , biochemistry , biology , gene , materials science , polymer , organic chemistry , transcription factor , political science , law , metallurgy
Wrapped around the finger : Tailored Cys 2 His 2 zinc‐finger domains can specifically bind to DNA when assisted by minor‐groove accessory interactions. In this way, appropriately designed hybrids containing the zinc‐finger unit of the GAGA factor and a distamycin‐like tripyrrole bind with high affinity to DNA sites that have a GAG triad near the 3′ side of an A‐rich fragment.