Specific DNA Recognition by a Synthetic, Monomeric Cys 2 His 2  Zinc‐Finger Peptide Conjugated to a Minor‐Groove Binder | Zendy

Vázquez Olalla | Zendy; Vázquez M. Eugenio | Zendy; Blanco Juan B. | Zendy; Castedo Luis | Zendy; Mascareñas José L. | Zendy

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Specific DNA Recognition by a Synthetic, Monomeric Cys 2 His 2 Zinc‐Finger Peptide Conjugated to a Minor‐Groove Binder

Author(s) -

Vázquez Olalla,

Vázquez M. Eugenio,

Blanco Juan B.,

Castedo Luis,

Mascareñas José L.

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702345

Subject(s) - zinc finger , monomer , dna , conjugated system , minor groove , minor (academic) , peptide , chemistry , zinc , computational biology , groove (engineering) , sequence (biology) , stereochemistry , combinatorial chemistry , computer science , biochemistry , biology , gene , materials science , polymer , organic chemistry , transcription factor , political science , law , metallurgy

Wrapped around the finger : Tailored Cys 2 His 2 zinc‐finger domains can specifically bind to DNA when assisted by minor‐groove accessory interactions. In this way, appropriately designed hybrids containing the zinc‐finger unit of the GAGA factor and a distamycin‐like tripyrrole bind with high affinity to DNA sites that have a GAG triad near the 3′ side of an A‐rich fragment.

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