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Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation
Author(s) -
Baratta Walter,
Chelucci Giorgio,
Herdtweck Eberhardt,
Magnolia Santo,
Siega Katia,
Rigo Pierluigi
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702278
Subject(s) - ruthenium , transfer hydrogenation , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Jumping Josiphos! Ruthenium cis ‐dichloro complexes with matched chiral diphosphane and aminopyridine ligands (see structure) are easily obtained by a one‐pot reaction of [RuCl 2 (PPh 3 ) 3 ] with a Josiphos diphosphane and racemic 1‐substituted 1‐(pyridin‐2‐yl)methanamine ligands. These complexes are highly active catalysts for the transfer hydrogenation of ketones, affording turnover frequencies of up to 70 000 h −1 at 60 °C and ee values up to 99 %.