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A Highly Selective Fluorescent Probe for Thiophenols
Author(s) -
Jiang Wei,
Fu Qingquan,
Fan Hongyou,
Ho Joe,
Wang Wei
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702271
Subject(s) - moiety , nucleophile , fluorescence , cysteine , cleavage (geology) , chemistry , combinatorial chemistry , glutathione , computer science , stereochemistry , biochemistry , materials science , catalysis , physics , quantum mechanics , fracture (geology) , composite material , enzyme
A rapid response to thiophenols is obtained with probe 1 (see scheme), which induces a significant (>50‐fold) fluorescence enhancement as a result of cleavage of the electron‐withdrawing moiety, thus generating strongly fluorescent molecule 2 . No fluorescence is obtained with aliphatic thiols, including cysteine and glutathione, or other nucleophiles.