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Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A
Author(s) -
Nicolaou K. C.,
Guduru Ramakrishna,
Sun YaPing,
Banerji Biswadip,
Chen David Y.K.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702243
Subject(s) - total synthesis , modular design , metathesis , ring closing metathesis , ring (chemistry) , closing (real estate) , stereochemistry , computer science , mathematics , chemistry , programming language , organic chemistry , political science , law , polymerization , polymer
In the palm of your hand : Total syntheses of the originally proposed and revised structures of the marine antitumor agent palmerolide A (see picture, originally proposed structure had opposite configurations at the positions indicated in red) were accomplished through a modular strategy that features a ring‐closing metathesis to stereoselectively form the C8C9 bond and concurrently form the macrocycle.