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Highly Regioselective Synthesis of Spirocyclic Compounds by a Palladium‐Catalyzed Intermolecular Tandem Reaction
Author(s) -
Bi HaiPeng,
Liu XueYuan,
Gou FaRong,
Guo LiNa,
Duan XinHua,
Shu XingZhong,
Liang YongMin
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702238
Subject(s) - regioselectivity , tandem , palladium , intermolecular force , catalysis , chemistry , combinatorial chemistry , cascade reaction , organic chemistry , molecule , materials science , composite material
Bicycles built for two : The palladium‐catalyzed intermolecular tandem reaction of propargylic compounds with 2‐iodophenols offers an efficient, direct route to spirocyclic compounds with high regioselectivity. The reaction conditions and the scope of the process are examined, and a possible mechanism is proposed.