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Amide‐to‐Ester Substitution in Coiled Coils: The Effect of Removing Hydrogen Bonds on Protein Structure
Author(s) -
Scheike Jessica A.,
Baldauf Carsten,
Spengler Jan,
Albericio Fernando,
Pisabarro M. Teresa,
Koksch Beate
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702218
Subject(s) - hydrogen bond , amide , substitution (logic) , coiled coil , molecular dynamics , chemistry , peptide bond , twist , peptide , crystallography , solvent , protein structure , side chain , computational chemistry , stereochemistry , molecule , organic chemistry , biochemistry , computer science , polymer , programming language , geometry , mathematics
The latest twist : The effect of backbone H‐bonding on the stability of proteins was studied by experimental techniques and molecular dynamics simulation. The structure of the coiled‐coil model peptide examined (see picture) is affected by interactions in the solvent‐exposed regions as well as by interhelical hydrophobic interactions.