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Organocatalysis Lost: Modern Chemistry, Ancient Chemistry, and an Unseen Biosynthetic Apparatus
Author(s) -
Barbas Carlos F.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702210
Subject(s) - organocatalysis , homochirality , chemistry , enantioselective synthesis , catalysis , biochemistry , amino acid
One enigma leads in three directions : The Hajos–Wiechert reaction presented an enigma that went unsolved for three decades. With the unravelling of this enigma, organocatalysis plays a major role in the development of efficient catalytic asymmetric methodologies. The mechanisms of organocatalysis also shed light on the origin of homochirality essential for life and provide clues to yet‐to‐be‐discovered biosynthetic mechanisms at work in living organisms today.