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Neutral Desorption Sampling of Living Objects for Rapid Analysis by Extractive Electrospray Ionization Mass Spectrometry
Author(s) -
Chen Huanwen,
Yang Shuiping,
Wortmann Arno,
Zenobi Renato
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702200
Subject(s) - mass spectrometry , sampling (signal processing) , desorption , sample (material) , chemistry , analytical chemistry (journal) , chromatography , computer science , electrospray ionization , environmental science , detector , organic chemistry , adsorption , telecommunications
MS comes to life : A novel method to sample surfaces of biological objects uses a neutral gas beam for in vivo EESI mass spectrometric analysis without sample pretreatment (see picture; QTOF=quadropole time‐of‐flight). The sampling process results in rapid in vivo analyses with reduced ion suppression and without chemical contamination. This strategy can be used in food quality monitoring, homeland security, metabolomics, and clinical diagnosis.