SimplePhos Monodentate Ligands: Synthesis and Application in Copper‐Catalyzed Reactions | Zendy

Palais Laëtitia | Zendy; Mikhel Igor S. | Zendy; Bournaud Chloée | Zendy; Micouin Laurent | Zendy; Falciola Caroline A. | Zendy; Vuagnouxd'Augustin Magali | Zendy; Rosset Stéphane | Zendy; Bernardinelli Gérald | Zendy; Alexakis Alexandre | Zendy

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SimplePhos Monodentate Ligands: Synthesis and Application in Copper‐Catalyzed Reactions

Author(s) -

Palais Laëtitia,

Mikhel Igor S.,

Bournaud Chloée,

Micouin Laurent,

Falciola Caroline A.,

Vuagnouxd'Augustin Magali,

Rosset Stéphane,

Bernardinelli Gérald,

Alexakis Alexandre

Publication year - 2007

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702186

Subject(s) - denticity , allylic rearrangement , copper , reagent , chemistry , combinatorial chemistry , zinc , catalysis , conjugate , aryl , carboxylate , medicinal chemistry , stereochemistry , organic chemistry , mathematics , crystal structure , mathematical analysis , alkyl

A simple choice : Ligands termed SimplePhos ( L* ), based on a chiral amino and flexible aryl groups on the phosphorus atom, induce high enantioselectivity in the copper‐catalyzed conjugate addition and allylic substitution of dialkyl zinc and trialkyl aluminum reagents (see scheme; CuTC=copper thiophene carboxylate).

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