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SimplePhos Monodentate Ligands: Synthesis and Application in Copper‐Catalyzed Reactions
Author(s) -
Palais Laëtitia,
Mikhel Igor S.,
Bournaud Chloée,
Micouin Laurent,
Falciola Caroline A.,
Vuagnouxd'Augustin Magali,
Rosset Stéphane,
Bernardinelli Gérald,
Alexakis Alexandre
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702186
Subject(s) - denticity , allylic rearrangement , copper , reagent , chemistry , combinatorial chemistry , zinc , catalysis , conjugate , aryl , carboxylate , medicinal chemistry , stereochemistry , organic chemistry , mathematics , crystal structure , mathematical analysis , alkyl
A simple choice : Ligands termed SimplePhos ( L* ), based on a chiral amino and flexible aryl groups on the phosphorus atom, induce high enantioselectivity in the copper‐catalyzed conjugate addition and allylic substitution of dialkyl zinc and trialkyl aluminum reagents (see scheme; CuTC=copper thiophene carboxylate).