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Direct Arylation of Thiazoles on Water
Author(s) -
Turner Gemma L.,
Morris James A.,
Greaney Michael F.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702141
Subject(s) - stoichiometry , aryl , chemistry , combinatorial chemistry , computer science , environmental science , database , organic chemistry , alkyl
Wetter is better : The direct arylation of thiazoles on water is quicker, cleaner, and higher‐yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5‐diaryl thiazoles in excellent yields. Importantly, novel bi‐heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents.