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Simple Heme Dimers with Strongly Cooperative Ligand Binding
Author(s) -
Khvostichenko Daria,
Yang QingZheng,
Boulatov Roman
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702120
Subject(s) - allosteric regulation , chemistry , heme , ligand (biochemistry) , hemoglobin , isocyanide , stereochemistry , crystallography , biophysics , biochemistry , receptor , biology , enzyme
Two is better than one : Fe II complexes of new porphyrins exist as dimers that bind small ligands cooperatively, as illustrated by the sigmoidal binding curve (fractional occupancy of binding sites, α , versus free‐ligand concentration, x ) for isocyanide Me 2 C 6 H 3 NC. An allosteric interaction energy of up to 13 kJ mol −1 —comparable to that of hemoglobin—is achieved in a simple structural motif.