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Experimental Determination of van der Waals Energies in a Biological System
Author(s) -
Wear Martin A.,
Kan Daphne,
Rabu Amir,
Walkinshaw Malcolm D.
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702084
Subject(s) - van der waals force , superposition principle , binding energy , crystallography , energy (signal processing) , crystal (programming language) , chemistry , physics , molecule , chemical physics , computer science , atomic physics , quantum mechanics , programming language
Gaze into the crystal : A crystallographic approach for determining and analyzing free energy not only provides a way of measuring binding energy, it also provides a detailed picture identifying, at the atomic level, which interactions are responsible for changes in binding affinity (picture: superposition of dipeptide–cyclophilin 3 structures; W e–h are conserved water molecules e–h).