Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1 | Zendy

Kuch David | Zendy; Schermelleh Lothar | Zendy; Manetto Susanne | Zendy; Leonhardt Heinrich | Zendy; Carell Thomas | Zendy

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Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1

Author(s) -

Kuch David,

Schermelleh Lothar,

Manetto Susanne,

Leonhardt Heinrich,

Carell Thomas

Publication year - 2008

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200702055

Subject(s) - dnmt1 , dna methylation , dna , dna methyltransferase , dumbbell , methyltransferase , epigenetics , chemistry , epigenomics , methylation , microbiology and biotechnology , enzyme , biochemistry , biology , gene , gene expression , physiology

Dumbbells that block : Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S‐adenosylmethionine, Fl=Cy3 fluorescence label, C N =5‐azadC, C‐Me=5‐methyldC).

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