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Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1
Author(s) -
Kuch David,
Schermelleh Lothar,
Manetto Susanne,
Leonhardt Heinrich,
Carell Thomas
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200702055
Subject(s) - dnmt1 , dna methylation , dna , dna methyltransferase , dumbbell , methyltransferase , epigenetics , chemistry , epigenomics , methylation , microbiology and biotechnology , enzyme , biochemistry , biology , gene , gene expression , physiology
Dumbbells that block : Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S‐adenosylmethionine, Fl=Cy3 fluorescence label, C N =5‐azadC, C‐Me=5‐methyldC).